Insulins

About insulin can write a lot, you can even book an entire sochinit.Poetomu I will write the most basic, so do not judge strictly!

And so a bit of history, theory:

Insulin in the sport of bodybuilding came in practice not so long ago, but according to some reviews, established unsurpassed anabolic itself. I’m not going to hang the label of “ignorant” to some reputable experts who consider the anabolic properties of insulin in sport is so prominent that even anabolic steroids with him a rest, and cautiously give my own opinion – for adults this hormone is not an anabolic general

Based on this fact, as well as the potential risk is not something that the health and life itself from the use of insulin in the sport, many foreign “gurus” recommend it to exclude from the bodybuilding arsenal. But we have something you are wise, we will not give in to emotions and rush from one extreme to the other, and try to just quietly throughout the deal. Insulin and its mechanism of action of insulin – a hormone secreted by the pancreas. Chemically sport insulin is a polypeptide comprising two polypeptide chains, one composed of 21 amino acids, the second – 30; These chains are interconnected by two disulfide bridges. Cells that produce hormones (many hormones, not only insulin) are concentrated in the pancreas in the form of islands, called the islets of Langerhans. An adult human of islets naschityvetsya from 170 thousand to 2 Mill., But their combined weight does not exceed 1.5% by weight of the pancreas. Among the islet cells are six different types, about 75% of them are in the cell, which, in fact, takes place insulin synthesis. This process takes place in three stages: the first is formed proproinsulin; then it split off from the hydrophobic moiety and is proinsulin; Further vesicle with proinsulin is transferred to the Golgi apparatus, where the cleaved fragment thereof, and the result is insulin.Triggers insulin secretion, glucose. Penetrating into cells, glucose metabolizirutsya and promotes intracellular ATP. ATP, in turn, causes depolarization of the cell membrane, which promotes the penetration of -cells and the release of calcium ions insulin. It must be said that the production of insulin, in addition to glucose, and may stimulate fatty acids and amino acids. Insulin was isolated in 1921, Canadian scientists Frederick Banting and his assistant Charles Best, Two years later, the two researchers were awarded for this discovery the Nobel Prize in medicine, and I must say, not in vain. The beginning of industrial production insulinosoderzhaschih drugs saved the lives of many, many thousands of people.But manufacturing production, and research had to move on, to stop this process is impossible. Alas, the result obtained in their knowledge does not even pretend to be complete. The mechanism of insulin hypoglycemic effect until the end has not yet been studied. It is believed that he (insulin) vzaimodeystvut to specific receptors on the cell surface. The resulting complex “+ insulin receptor” penetrates into the cells where insulin is released and exerts its effect. The action of insulin in bodybuilding activates glucose transport through the cell membrane and its utilization in muscle and adipose tissues. Under the influence of insulin increases glycogen synthesis, insulin inhibits the conversion of amino acids into glucose (which is why it is useful to inject insulin immediately after exercise – consumed after this protein is not on the energy needs, as it usually happens, and muscle tissue regeneration, and the one who theoretical part accustomed to pass, never know about it). In addition, insulin promotes the action bodybuilding delivery into a cell more amino acids, and, more significantly. And this, as you can imagine, can not but have a positive impact on growth (hypertrophy) of the muscle fibers. But with respect to the action of insulin in bodybuilding stimulate protein synthesis is not all clear; yet this ability, and I must say, is quite pronounced, this hormone is seen only in a few experiments in which managed to achieve local insulin concentration more than a thousand (!) times greater than the norm. With this concentration of insulin began to successfully perform the functions of insulin growth factor that in nature is not characteristic for it. Wishing to see firsthand the effectiveness of insulin as an anabolic just want to warn: self-repetition of such an experiment “at home” could be the last act in the earthly life of the experimenter. In summary, we can say that insulin is able to prevent the destruction of muscle fibers, which has the purpose of replenishment of energy reserves of the organism, as well as to strengthen the delivery of amino acids in the cell – this is its main attraction. The negative qualities of insulin should be its ability to enhance the deposition of triglycerides in adipose tissue which leads to an increase in subcutaneous fat. However, with the recent phenomenon once again to fight something and you can, but this is a little lower. This “sweet” word “diabetes” The normal blood glucose level varies in the range of 70-110 mg / dl, dropping below 70 mg / dL is considered a hypoglycemic state, exceeding the upper limit is considered normal within 2-3 hours after a meal – at the end of this time, blood glucose levels should return to normal limits. If the blood glucose level after meal mark exceeds 180 mg / dl is considered hyperglycemic state. Well, if the above-mentioned level of one person after an aqueous solution of sugar intake exceeded 200 mg / dL, but not once, but during the two tests, then this condition is classified as diabetes. Now a little about diabetes: There are two types of diabetes – insulin and non-insulin. In insulin-dependent diabetes (type 1 diabetes) accounts for about 30% of all cases of diabetes (according to the US Department of Health of not more than 10%, but this data is for the US only, although it is unlikely the people of this country so strikingly different from the rest of the earthlings). It arises as a result of disturbances in the human immune system: the formation of antibodies to the antigens of the islets of Langerhans, which reduces the number of active cells and therefore production to a drop in insulin levels. Insulin-dependent diabetes occurs usually in childhood or adolescence (mean age of diagnosis – 14 years old) or adult (rarely) under the influence of various toxins, trauma, complete removal of pancreatic disease or as accompanying acromegaly. The nature of insulin-dependent diabetes do not really understood, it is believed that a person must be predisposed genetically to that, to get this evil disease. Turning to type 2 diabetes (non-insulin dependent), it should be noted that the concentration of cell surface receptors (and they include receptors insulin) depends, among other things, on the level of hormones in the blood. If the level increases, the corresponding number of hormone receptors is reduced, i.e. actually occurs decrease cell sensitivity to the hormone which is in excess in the blood. And vice versa. Type 2 diabetes arises just in adults and only them – in middle age (30-40 years) or even later. As a rule, these are people who suffer from being overweight, although there are exceptions. Again, as a rule, endogenous insulin production level in such people is normal or even exceeds it. Then what is the matter? And it is in the downregulation of insulin receptors on the cell surface. Continuous excessive intake of fat and carbohydrates leads to a constant level of the increased insulin levels, which in turn leads to a reduction in the irreversible including, among the above-mentioned receptors.Not all, however, people who are obese, insulin-dependent diabetes develops. Approximately half of all patients receive it “inherited”, ie has a predisposition to the disease. Why are we suddenly talking about diabetes? And here’s why. It is believed that the use of insulin healthy person can lead to the development of this disease is just. As for insulin-dependent diabetes (type 1), then all seems clear – excess insulin in a healthy organism turn this disease does not threaten. Another thing – non-insulin dependent diabetes. The addition of insulin over a long period of time can, like excessive consumption of carbohydrates and fats, cause permanent reduction in the number of insulin receptors on the cell surface, and so – and to a sustainable reduction in the ability of cells to utilize glucose, ie . diabetes type 2. In theory, everything seems to be so. In the real world there is hardly even one person (I mean – fully healthy person, including mentally), who for the sake of athletic achievement stabbed himself insulin without interruption for years. A period of less than two to three years, is unlikely to lead to any shift in the direction of the disease. There is, however, a risk group, it includes people having a hereditary tendency to develop diabetes. These people should not experiment with insulin at all. And another small question for he regards growth hormone and its effects on the production of endogenous insulin. Hypoglycemic condition stimulates increased secretion of growth hormone, which, as adrenaline and noradrenaline, has the ability to inhibit the production of insulin. There is, however, evidence that the frequent use of high doses of growth hormone may lead to a decrease in the number of active cells, and hence a the development of diabetes type 1. If so, then the probability of such an outcome is negligible. And again summarize the above: the use of healthy insulin having no family history of diabetes, people do not lead to the development of their disease. Injection Practice Well, finally – with the theoretical part we are finished and realized that the bodybuilder as an ordinary “rocking” and professional, insulin can help in his difficult path. Application: It is time to apply this knowledge in practice. I have to say: independent of insulin injections for the beginner – employment insecurity. It’s not steroids stabbing: You can dial the same testosterone, but in the syringe will get, and still – no threat to life. The course of insulin in bodybuilding – is another matter, an error in its dosage can easily send you in the best of all possible worlds. One consolation – death will be painless enough. Well, the parrot – and that’s enough.If you have available a sufficient number of what are called common sense, then you afraid nothing special. One need only remember a few simple rules and follow them with great care. Usually recommend starting insulin course in bodybuilding with 4 IU (international units, is 4 points on the units scale for a special insulin syringe and other syringe use is strictly prohibited!). I was, however, unknown cases of hypoglycemic coma, resulting from the introduction and twice the dose therefore I recommend all the same to start with her. Next dose should increase daily, in small steps, 2-4 IU, until one of two things: you will reach the mark of 20 IU or feel a very strong hypoglycemia after administration of a lower dose. The course of insulin in bodybuilding higher doses is hardly justified, and 20 IU may be considered more safe enough level. Most people have serious problems begin with the dosages of the order of 35-45 IU, but, again, not so rare and cases of hypoglycemic coma after administration 22-25 IU, especially if the injection was performed during or immediately after exercise. so try not to rise above 20 IU of insulin in one injection, if any, carried out before, during or immediately after a workout, it’s best to its volume no more than 15-16 IU. All this relates to insulin and short-acting. With intermediate-acting insulin and a “mix” all a bit different, but this is slightly lower. What is possible to use insulin? Quick action (Humalog) 10 minutes 1.5 hours 5 hours 2-4 hours Short-acting (Humulin R) 20 minutes 3-4 hour 8 hours 3-6 hours average duration (Humulin NPH) 1.5-2 hours 4-6 hours 22 hours 10-14 hours of average duration (Humulin R) 1.5-2 hours 11-13 hours 24 hours 14 18 hours Long-acting (Humulin U) 4 hours 12-16 hours 26 hours 18-22 hourscombination of Humalog Mix 75/25 (75% Humulin NPL + 25% Humalog) 10 minutes 1.5-2 hours 16-20 hours 10-14 hours combination of Humulin 70/30 (70% Humulin NPH + 30% Humulin R) 0-1 hours 3-13 hours 18-22 hours 10-14 hours combination of Humulin 50/50 (50% Humulin NPH + 50% Humulin R) 0 -1 hour 2-6 hours 16-20 hours 10-14 hours most acceptable in sports practice is the use of insulin short (usually a “Humulin R” production company “Eli Lilly”) or ultrashort ( “Humalog” from the same manufacturer) actions. People experienced can recommend the use of intermediate-acting insulin, usually in combination with a “short” or “ultra” insulin or “mixes”. On peculiarities of application of “ultrashort” insulins and “mixes”, see the relevant chapter. Syringes for insulin and number of units in one milliliter: Look at these photos: Before your insulin syringes, insulin injections can be done only with their help. One division of the syringe corresponds to one IU of insulin. Pay attention to the marking – various insulin syringes are available for preparations containing 40 IU per milliliter and 100 IU per milliliter. Last on our market practically do not fall, but “almost” does not mean -. “Absolutely” Man, accustomed to traditional insulin concentration, which fell into the hands of the drug at a concentration of 100 IU of insulin per ml, can easily exceed the dosage of 2.5 times that is likely to lead to irreparable consequences! Pay attention to the concentration of insulin in the solution and use only the corresponding syringes! Hypoglycemia: I have already said that it is not impossible to learn hypoglycemia. However, for someone who is getting ready for the first use of insulin, I try to describe her symptoms. Here they are: ▪ sharp sweating▪ acute hunger ▪ difficulties with coordination and orientation in space ▪ blurred vision (circles before my eyes) ▪ speech disorders ▪ trembling limbs ▪ changes in heart rate – the heart starts to beat faster ▪ drowsiness ▪ increase in insecurity feelings, panic ▪ mood changes – euphoria or irritability buildup ▪ change of behavior – behavior gets you previously uncharacteristic traits trouble is that when a significant excess of the permissible dose of insulin the symptoms are growing very rapidly, and people often do not have time to understand anything. The result – a complete disorientation, loss of consciousness or involuntary falling asleep, and – possibly fatal. Therefore, it is desirable that within 2-4 hours from the time of the insulin injection, especially if it is done for the first time, you would have been close to someone who will not let you sleep, sweet feed (feed it – at the time of hypoglycemia is often the person does not It understands what to do), and in particularly serious cases, will be able to make an intravenous injection of glucose or adrenaline and call a doctor. new insulin Perhaps we should not talk about new preparations of insulin in our market, and new drugs in sports practice. Some features in comparison with the already familiar short-acting insulin, insulin has a rapid-acting, presented in our market is that only one drug – a “Novorapid” company “Novo Nordisk”. It is not discharged with traditional vials and cartridges for use in the pen. Since the syringe-pen – fun quite expensive, used for the abstraction of the cartridge can be a conventional insulin syringe in the cartridge is no different from the vial. The increase in the concentration of insulin in the blood in the case of the drug-acting is more pronounced than in the case of insulin index “P” peak somewhat steeper even when applying the same dose. Hypoglycemia is more stable and unable to get out of it with great difficulty. Therefore, in the case of “ultrashort” insulin can be encouraged to use 70-80% of your regular dose of “short” of insulin. As for the “mix” their is that our market there, but in the near future, and their appearance is expected. But out of the situation is possible by simultaneous injection of 8-10 IU “ultra” or 10-12 IU insulin “short” (note – or, not together!) With 20-30 IU intermediate-acting insulin. In this case, the first peak is reached fairly rapidly – within an hour and a half, an increased insulin level in blood is kept for 10-14 hours at a second, much weaker peak in the range of 4-5 hours after injection. Use of insulin under the scheme is strongly recommended that only in the morning. To apply this scheme in training days can afford only experienced athletes. By experience, I am not referring to the experience of training and experience of the use of insulin. Tested Regimen containing insulin : The usual practice – the injection of insulin in the morning on an empty stomach or immediately after meals. In the first case, injection is done for 20-30 minutes before the first meal. This is the meal can be (and in the case of training – you need to, because there is no alternative) to replace the cocktail, which should ideally contain the following substances: ▪ 50-60 grams of whey protein; ▪ carbohydrate (dextrose or fructose) at the rate of 6-10 grams 1 IU of insulin injected; ▪ 5-7 grams of creatine; . ▪ 5-7 grams of glutamine last two items are not necessary if you are taking AAS concurrently with taking insulin. After an hour and a half after the cocktail must be followed normal meal. But the most sense is the use of insulin immediately after exercise, or better yet, for 15-20 minutes until it ends. Another option – insulin injection just before training with immediately following her taking amino acids and carbohydrate drink (the calculation is the same – 6-10 grams of fructose or dextrose to 1 IU injected insulin). However, the latter two options can be recommended only for those who already have experience in dealing with hypoglycemia. The use of insulin before or after a workout has two advantages: firstly, hypoglycemia induced by administration of exogenous insulin, in addition to natural decline in blood sugar during studies with “iron”, which makes a stronger release of growth hormone in the blood; Second, insulin inhibits the conversion of amino acids into glucose, and thus – a guarantee that the protein in your post-workout drink, do not go solely on the resumption of the body depleted energy reserves. In small doses of insulin – 8-12 IU two to three times per day, usually after meals – insulin can be used as a means of enhancing the effect of the application of AAS – in this case, the property to increase the permeability of its cell membrane.However, we must not forget that high doses of aromatizing steroids can promote the deposition of fat on the female type (ie, in the most inappropriate places for this – on the hips and waist) and of themselves, and the dose of insulin, this process will only intensify. Therefore, as far as possible need to limit yourself to non-aromatizing steroids, the benefit of their choice is quite large. So a specialist in dietetics as Chad Nicholls, the following scheme is the use of a dose of insulin was introduced, based on the above principles. Insulin is used every three or four days, in the day of training. In the morning, on an empty stomach is an injection of 16-24 IU of insulin; during a workout, 15-20 minutes prior to the end – another – 12-18 IU; night, no less than 6 hours before bedtime – the last – 12-16 IU. Suitable naturally only insulin or short-acting. The use of insulin dose by this scheme helps to avoid a certain degree of accumulation of body fat and improve insulin resistance even if not used auxiliary agents such as metformin. The use of the hormone in the training days helps to significantly reduce the rate of catabolism in the body. Finally, there is a scheme of insulin on the background of a low-carb diet. This variant of the drug, generally provides a significant gain in lean muscle mass, even if insulin – only one applied in this period drugs (insulin discussed above is used a property substantially slowing catabolic processes in the body). I stress – muscle mass turns it dry, no fat, no water in this case, the body does not accumulate. This scheme of the drug is used, usually in preparation for the competition, which will take a drug test. It should be immediately noted that this scheme is very hard to bear – protein intake rises to 6-7 g per kg dry weight, and water – up to 5-6 liters a day! (Use the fact that hypoglycemia “quenching” can not only carbohydrates but also protein and fluid overdose). I deliberately give here only general reasoning for this scheme, as its use requires strict monitoring by an experienced specialist! Then what is the matter? And it is in the downregulation of insulin receptors on the cell surface. Continuous excessive intake of fat and carbohydrates leads to a constant level of the increased insulin levels, which in turn leads to a reduction in the irreversible including, among the above-mentioned receptors. Not all, however, people who are obese, insulin-dependent diabetes develops. Approximately half of all patients receive it “inherited”, ie has a predisposition to the disease. Why are we suddenly talking about diabetes? And here’s why. It is believed that the use of insulin healthy person can lead to the development of this disease is just. As for insulin-dependent diabetes (type 1), then all seems clear – excess insulin in a healthy organism turn this disease does not threaten. Another thing – non-insulin dependent diabetes. The addition of insulin over a long period of time can, like excessive consumption of carbohydrates and fats, cause permanent reduction in the number of insulin receptors on the cell surface, and so – and to a sustainable reduction in the ability of cells to utilize glucose, ie . diabetes type 2. In theory, everything seems to be so. In the real world there is hardly even one person (I mean – fully healthy person, including mentally), who for the sake of athletic achievement stabbed himself insulin without interruption for years. A period of less than two to three years, is unlikely to lead to any shift in the direction of the disease. There is, however, a risk group, it includes people having a hereditary tendency to develop diabetes. These people should not experiment with insulin at all. And another small question for he regards growth hormone and its effects on the production of endogenous insulin. Hypoglycemic condition stimulates increased secretion of growth hormone, which, as adrenaline and noradrenaline, has the ability to inhibit the production of insulin. There is, however, evidence that the frequent use of high doses of growth hormone may lead to a decrease in the number of active cells, and hence a the development of diabetes type 1. If so, then the probability of such an outcome is negligible. And again summarize the above: the use of healthy insulin having no family history of diabetes, people do not lead to the development of their disease. Injection Practice Well, finally – with the theoretical part we are finished and realized that the bodybuilder as an ordinary “rocking” and professional, insulin can help in his difficult path. Application: It is time to apply this knowledge in practice. I have to say: independent of insulin injections for the beginner – employment insecurity. It’s not steroids stabbing: You can dial the same testosterone, but in the syringe will get, and still – no threat to life. The course of insulin in bodybuilding – is another matter, an error in its dosage can easily send you in the best of all possible worlds. One consolation – death will be painless enough. Well, the parrot – and that’s enough. If you have available a sufficient number of what are called common sense, then you afraid nothing special. One need only remember a few simple rules and follow them with great care. Usually recommend starting insulin course in bodybuilding with 4 IU (international units, is 4 points on the units scale for a special insulin syringe and other syringe use is strictly prohibited!). I was, however, unknown cases of hypoglycemic coma, resulting from the introduction and twice the dose therefore I recommend all the same to start with her. Next dose should increase daily, in small steps, 2-4 IU, until one of two things: you will reach the mark of 20 IU or feel a very strong hypoglycemia after administration of a lower dose. The course of insulin in bodybuilding higher doses is hardly justified, and 20 IU may be considered more safe enough level. Most people have serious problems begin with the dosages of the order of 35-45 IU, but, again, not so rare and cases of hypoglycemic coma after administration 22-25 IU, especially if the injection was performed during or immediately after exercise. so try not to rise above 20 IU of insulin in one injection, if any, carried out before, during or immediately after a workout, it’s best to its volume no more than 15-16 IU. All this relates to insulin and short-acting. With intermediate-acting insulin and a “mix” all a bit different, but this is slightly lower. What is possible to use insulin? Quick action (Humalog) 10 minutes 1.5 hours 5 hours 2-4 hours Short-acting (Humulin R) 20 minutes 3-4 hour 8 hours 3-6 hours average duration (Humulin NPH) 1.5-2 hours 4-6 hours 22 hours 10-14 hours of average duration (Humulin R) 1.5-2 hours 11-13 hours 24 hours 14 18 hours Long-acting (Humulin U) 4 hours 12-16 hours 26 hours 18-22 hourscombination of Humalog Mix 75/25 (75% Humulin NPL + 25% Humalog) 10 minutes 1.5-2 hours 16-20 hours 10-14 hours combination of Humulin 70/30 (70% Humulin NPH + 30% Humulin R) 0-1 hours 3-13 hours 18-22 hours 10-14 hours combination of Humulin 50/50 (50% Humulin NPH + 50% Humulin R) 0 -1 hour 2-6 hours 16-20 hours 10-14 hours most acceptable in sports practice is the use of insulin short (usually a “Humulin R” production company “Eli Lilly”) or ultrashort ( “Humalog” from the same manufacturer) actions. People experienced can recommend the use of intermediate-acting insulin, usually in combination with a “short” or “ultra” insulin or “mixes”. On peculiarities of application of “ultrashort” insulins and “mixes”, see the relevant chapter. Syringes for insulin and number of units in one milliliter: Look at these photos: Before your insulin syringes, insulin injections can be done only with their help. One division of the syringe corresponds to one IU of insulin. Pay attention to the marking – various insulin syringes are available for preparations containing 40 IU per milliliter and 100 IU per milliliter. Last on our market practically do not fall, but “almost” does not mean -. “Absolutely” Man, accustomed to traditional insulin concentration, which fell into the hands of the drug at a concentration of 100 IU of insulin per ml, can easily exceed the dosage of 2.5 times that is likely to lead to irreparable consequences! Pay attention to the concentration of insulin in the solution and use only the corresponding syringes! Hypoglycemia: I have already said that it is not impossible to learn hypoglycemia. However, for someone who is getting ready for the first use of insulin, I try to describe her symptoms. Here they are: ▪ sharp sweating▪ acute hunger ▪ difficulties with coordination and orientation in space ▪ blurred vision (circles before my eyes) ▪ speech disorders ▪ trembling limbs ▪ changes in heart rate – the heart starts to beat faster ▪ drowsiness ▪ increase in insecurity feelings, panic ▪ mood changes – euphoria or irritability buildup ▪ change of behavior – behavior gets you previously uncharacteristic traits trouble is that when a significant excess of the permissible dose of insulin the symptoms are growing very rapidly, and people often do not have time to understand anything. The result – a complete disorientation, loss of consciousness or involuntary falling asleep, and – possibly fatal. Therefore, it is desirable that within 2-4 hours from the time of the insulin injection, especially if it is done for the first time, you would have been close to someone who will not let you sleep, sweet feed (feed it – at the time of hypoglycemia is often the person does not It understands what to do), and in particularly serious cases, will be able to make an intravenous injection of glucose or adrenaline and call a doctor. new insulin Perhaps we should not talk about new preparations of insulin in our market, and new drugs in sports practice. Some features in comparison with the already familiar short-acting insulin, insulin has a rapid-acting, presented in our market is that only one drug – a “Novorapid” company “Novo Nordisk”. It is not discharged with traditional vials and cartridges for use in the pen. Since the syringe-pen – fun quite expensive, used for the abstraction of the cartridge can be a conventional insulin syringe in the cartridge is no different from the vial. The increase in the concentration of insulin in the blood in the case of the drug-acting is more pronounced than in the case of insulin index “P” peak somewhat steeper even when applying the same dose. Hypoglycemia is more stable and unable to get out of it with great difficulty. Therefore, in the case of “ultrashort” insulin can be encouraged to use 70-80% of your regular dose of “short” of insulin. As for the “mix” their is that our market there, but in the near future, and their appearance is expected. But out of the situation is possible by simultaneous injection of 8-10 IU “ultra” or 10-12 IU insulin “short” (note – or, not together!) With 20-30 IU intermediate-acting insulin. In this case, the first peak is reached fairly rapidly – within an hour and a half, an increased insulin level in blood is kept for 10-14 hours at a second, much weaker peak in the range of 4-5 hours after injection. Use of insulin under the scheme is strongly recommended that only in the morning. To apply this scheme in training days can afford only experienced athletes. By experience, I am not referring to the experience of training and experience of the use of insulin. Tested Regimen containing insulin : The usual practice – the injection of insulin in the morning on an empty stomach or immediately after meals. In the first case, injection is done for 20-30 minutes before the first meal. This is the meal can be (and in the case of training – you need to, because there is no alternative) to replace the cocktail, which should ideally contain the following substances: ▪ 50-60 grams of whey protein; ▪ carbohydrate (dextrose or fructose) at the rate of 6-10 grams 1 IU of insulin injected; ▪ 5-7 grams of creatine; . ▪ 5-7 grams of glutamine last two items are not necessary if you are taking AAS concurrently with taking insulin. After an hour and a half after the cocktail must be followed normal meal. But the most sense is the use of insulin immediately after exercise, or better yet, for 15-20 minutes until it ends. Another option – insulin injection just before training with immediately following her taking amino acids and carbohydrate drink (the calculation is the same – 6-10 grams of fructose or dextrose to 1 IU injected insulin). However, the latter two options can be recommended only for those who already have experience in dealing with hypoglycemia. The use of insulin before or after a workout has two advantages: firstly, hypoglycemia induced by administration of exogenous insulin, in addition to natural decline in blood sugar during studies with “iron”, which makes a stronger release of growth hormone in the blood; Second, insulin inhibits the conversion of amino acids into glucose, and thus – a guarantee that the protein in your post-workout drink, do not go solely on the resumption of the body depleted energy reserves. In small doses of insulin – 8-12 IU two to three times per day, usually after meals – insulin can be used as a means of enhancing the effect of the application of AAS – in this case, the property to increase the permeability of its cell membrane.However, we must not forget that high doses of aromatizing steroids can promote the deposition of fat on the female type (ie, in the most inappropriate places for this – on the hips and waist) and of themselves, and the dose of insulin, this process will only intensify. Therefore, as far as possible need to limit yourself to non-aromatizing steroids, the benefit of their choice is quite large. So a specialist in dietetics as Chad Nicholls, the following scheme is the use of a dose of insulin was introduced, based on the above principles. Insulin is used every three or four days, in the day of training. In the morning, on an empty stomach is an injection of 16-24 IU of insulin; during a workout, 15-20 minutes prior to the end – another – 12-18 IU; night, no less than 6 hours before bedtime – the last – 12-16 IU. Suitable naturally only insulin or short-acting. The use of insulin dose by this scheme helps to avoid a certain degree of accumulation of body fat and improve insulin resistance even if not used auxiliary agents such as metformin. The use of the hormone in the training days helps to significantly reduce the rate of catabolism in the body. Finally, there is a scheme of insulin on the background of a low-carb diet. This variant of the drug, generally provides a significant gain in lean muscle mass, even if insulin – only one applied in this period drugs (insulin discussed above is used a property substantially slowing catabolic processes in the body). I stress – muscle mass turns it dry, no fat, no water in this case, the body does not accumulate. This scheme of the drug is used, usually in preparation for the competition, which will take a drug test. It should be immediately noted that this scheme is very hard to bear – protein intake rises to 6-7 g per kg dry weight, and water – up to 5-6 liters a day! (Use the fact that hypoglycemia “quenching” can not only carbohydrates but also protein and fluid overdose). I deliberately give here only general reasoning for this scheme, as its use requires strict monitoring by an experienced specialist! Then what is the matter? And it is in the downregulation of insulin receptors on the cell surface. Continuous excessive intake of fat and carbohydrates leads to a constant level of the increased insulin levels, which in turn leads to a reduction in the irreversible including, among the above-mentioned receptors. Not all, however, people who are obese, insulin-dependent diabetes develops. Approximately half of all patients receive it “inherited”, ie has a predisposition to the disease. Why are we suddenly talking about diabetes? And here’s why. It is believed that the use of insulin healthy person can lead to the development of this disease is just. As for insulin-dependent diabetes (type 1), then all seems clear – excess insulin in a healthy organism turn this disease does not threaten. Another thing – non-insulin dependent diabetes. The addition of insulin over a long period of time can, like excessive consumption of carbohydrates and fats, cause permanent reduction in the number of insulin receptors on the cell surface, and so – and to a sustainable reduction in the ability of cells to utilize glucose, ie . diabetes type 2. In theory, everything seems to be so. In the real world there is hardly even one person (I mean – fully healthy person, including mentally), who for the sake of athletic achievement stabbed himself insulin without interruption for years. A period of less than two to three years, is unlikely to lead to any shift in the direction of the disease. There is, however, a risk group, it includes people having a hereditary tendency to develop diabetes. These people should not experiment with insulin at all. And another small question for he regards growth hormone and its effects on the production of endogenous insulin. Hypoglycemic condition stimulates increased secretion of growth hormone, which, as adrenaline and noradrenaline, has the ability to inhibit the production of insulin. There is, however, evidence that the frequent use of high doses of growth hormone may lead to a decrease in the number of active cells, and hence a the development of diabetes type 1. If so, then the probability of such an outcome is negligible. And again summarize the above: the use of healthy insulin having no family history of diabetes, people do not lead to the development of their disease. Injection Practice Well, finally – with the theoretical part we are finished and realized that the bodybuilder as an ordinary “rocking” and professional, insulin can help in his difficult path. Application: It is time to apply this knowledge in practice. I have to say: independent of insulin injections for the beginner – employment insecurity. It’s not steroids stabbing: You can dial the same testosterone, but in the syringe will get, and still – no threat to life. The course of insulin in bodybuilding – is another matter, an error in its dosage can easily send you in the best of all possible worlds. One consolation – death will be painless enough. Well, the parrot – and that’s enough. If you have available a sufficient number of what are called common sense, then you afraid nothing special. One need only remember a few simple rules and follow them with great care. Usually recommend starting insulin course in bodybuilding with 4 IU (international units, is 4 points on the units scale for a special insulin syringe and other syringe use is strictly prohibited!). I was, however, unknown cases of hypoglycemic coma, resulting from the introduction and twice the dose therefore I recommend all the same to start with her. Next dose should increase daily, in small steps, 2-4 IU, until one of two things: you will reach the mark of 20 IU or feel a very strong hypoglycemia after administration of a lower dose. The course of insulin in bodybuilding higher doses is hardly justified, and 20 IU may be considered more safe enough level. Most people have serious problems begin with the dosages of the order of 35-45 IU, but, again, not so rare and cases of hypoglycemic coma after administration 22-25 IU, especially if the injection was performed during or immediately after exercise. so try not to rise above 20 IU of insulin in one injection, if any, carried out before, during or immediately after a workout, it’s best to its volume no more than 15-16 IU. All this relates to insulin and short-acting. With intermediate-acting insulin and a “mix” all a bit different, but this is slightly lower. What is possible to use insulin? Quick action (Humalog) 10 minutes 1.5 hours 5 hours 2-4 hours Short-acting (Humulin R) 20 minutes 3-4 hour 8 hours 3-6 hours average duration (Humulin NPH) 1.5-2 hours 4-6 hours 22 hours 10-14 hours of average duration (Humulin R) 1.5-2 hours 11-13 hours 24 hours 14 18 hours Long-acting (Humulin U) 4 hours 12-16 hours 26 hours 18-22 hourscombination of Humalog Mix 75/25 (75% Humulin NPL + 25% Humalog) 10 minutes 1.5-2 hours 16-20 hours 10-14 hours combination of Humulin 70/30 (70% Humulin NPH + 30% Humulin R) 0-1 hours 3-13 hours 18-22 hours 10-14 hours combination of Humulin 50/50 (50% Humulin NPH + 50% Humulin R) 0 -1 hour 2-6 hours 16-20 hours 10-14 hours most acceptable in sports practice is the use of insulin short (usually a “Humulin R” production company “Eli Lilly”) or ultrashort ( “Humalog” from the same manufacturer) actions. People experienced can recommend the use of intermediate-acting insulin, usually in combination with a “short” or “ultra” insulin or “mixes”. On peculiarities of application of “ultrashort” insulins and “mixes”, see the relevant chapter. Syringes for insulin and number of units in one milliliter: Look at these photos: Before your insulin syringes, insulin injections can be done only with their help. One division of the syringe corresponds to one IU of insulin. Pay attention to the marking – various insulin syringes are available for preparations containing 40 IU per milliliter and 100 IU per milliliter. Last on our market practically do not fall, but “almost” does not mean -. “Absolutely” Man, accustomed to traditional insulin concentration, which fell into the hands of the drug at a concentration of 100 IU of insulin per ml, can easily exceed the dosage of 2.5 times that is likely to lead to irreparable consequences! Pay attention to the concentration of insulin in the solution and use only the corresponding syringes! Hypoglycemia: I have already said that it is not impossible to learn hypoglycemia. However, for someone who is getting ready for the first use of insulin, I try to describe her symptoms. Here they are: ▪ sharp sweating▪ acute hunger ▪ difficulties with coordination and orientation in space ▪ blurred vision (circles before my eyes) ▪ speech disorders ▪ trembling limbs ▪ changes in heart rate – the heart starts to beat faster ▪ drowsiness ▪ increase in insecurity feelings, panic ▪ mood changes – euphoria or irritability buildup ▪ change of behavior – behavior gets you previously uncharacteristic traits trouble is that when a significant excess of the permissible dose of insulin the symptoms are growing very rapidly, and people often do not have time to understand anything. The result – a complete disorientation, loss of consciousness or involuntary falling asleep, and – possibly fatal. Therefore, it is desirable that within 2-4 hours from the time of the insulin injection, especially if it is done for the first time, you would have been close to someone who will not let you sleep, sweet feed (feed it – at the time of hypoglycemia is often the person does not It understands what to do), and in particularly serious cases, will be able to make an intravenous injection of glucose or adrenaline and call a doctor. new insulin Perhaps we should not talk about new preparations of insulin in our market, and new drugs in sports practice. Some features in comparison with the already familiar short-acting insulin, insulin has a rapid-acting, presented in our market is that only one drug – a “Novorapid” company “Novo Nordisk”. It is not discharged with traditional vials and cartridges for use in the pen. Since the syringe-pen – fun quite expensive, used for the abstraction of the cartridge can be a conventional insulin syringe in the cartridge is no different from the vial. The increase in the concentration of insulin in the blood in the case of the drug-acting is more pronounced than in the case of insulin index “P” peak somewhat steeper even when applying the same dose. Hypoglycemia is more stable and unable to get out of it with great difficulty. Therefore, in the case of “ultrashort” insulin can be encouraged to use 70-80% of your regular dose of “short” of insulin. As for the “mix” their is that our market there, but in the near future, and their appearance is expected. But out of the situation is possible by simultaneous injection of 8-10 IU “ultra” or 10-12 IU insulin “short” (note – or, not together!) With 20-30 IU intermediate-acting insulin. In this case, the first peak is reached fairly rapidly – within an hour and a half, an increased insulin level in blood is kept for 10-14 hours at a second, much weaker peak in the range of 4-5 hours after injection. Use of insulin under the scheme is strongly recommended that only in the morning. To apply this scheme in training days can afford only experienced athletes. By experience, I am not referring to the experience of training and experience of the use of insulin. Tested Regimen containing insulin : The usual practice – the injection of insulin in the morning on an empty stomach or immediately after meals. In the first case, injection is done for 20-30 minutes before the first meal. This is the meal can be (and in the case of training – you need to, because there is no alternative) to replace the cocktail, which should ideally contain the following substances: ▪ 50-60 grams of whey protein; ▪ carbohydrate (dextrose or fructose) at the rate of 6-10 grams 1 IU of insulin injected; ▪ 5-7 grams of creatine; . ▪ 5-7 grams of glutamine last two items are not necessary if you are taking AAS concurrently with taking insulin. After an hour and a half after the cocktail must be followed normal meal. But the most sense is the use of insulin immediately after exercise, or better yet, for 15-20 minutes until it ends. Another option – insulin injection just before training with immediately following her taking amino acids and carbohydrate drink (the calculation is the same – 6-10 grams of fructose or dextrose to 1 IU injected insulin). However, the latter two options can be recommended only for those who already have experience in dealing with hypoglycemia. The use of insulin before or after a workout has two advantages: firstly, hypoglycemia induced by administration of exogenous insulin, in addition to natural decline in blood sugar during studies with “iron”, which makes a stronger release of growth hormone in the blood; Second, insulin inhibits the conversion of amino acids into glucose, and thus – a guarantee that the protein in your post-workout drink, do not go solely on the resumption of the body depleted energy reserves. In small doses of insulin – 8-12 IU two to three times per day, usually after meals – insulin can be used as a means of enhancing the effect of the application of AAS – in this case, the property to increase the permeability of its cell membrane.However, we must not forget that high doses of aromatizing steroids can promote the deposition of fat on the female type (ie, in the most inappropriate places for this – on the hips and waist) and of themselves, and the dose of insulin, this process will only intensify. Therefore, as far as possible need to limit yourself to non-aromatizing steroids, the benefit of their choice is quite large. So a specialist in dietetics as Chad Nicholls, the following scheme is the use of a dose of insulin was introduced, based on the above principles. Insulin is used every three or four days, in the day of training. In the morning, on an empty stomach is an injection of 16-24 IU of insulin; during a workout, 15-20 minutes prior to the end – another – 12-18 IU; night, no less than 6 hours before bedtime – the last – 12-16 IU. Suitable naturally only insulin or short-acting. The use of insulin dose by this scheme helps to avoid a certain degree of accumulation of body fat and improve insulin resistance even if not used auxiliary agents such as metformin. The use of the hormone in the training days helps to significantly reduce the rate of catabolism in the body. Finally, there is a scheme of insulin on the background of a low-carb diet. This variant of the drug, generally provides a significant gain in lean muscle mass, even if insulin – only one applied in this period drugs (insulin discussed above is used a property substantially slowing catabolic processes in the body). I stress – muscle mass turns it dry, no fat, no water in this case, the body does not accumulate. This scheme of the drug is used, usually in preparation for the competition, which will take a drug test. It should be immediately noted that this scheme is very hard to bear – protein intake rises to 6-7 g per kg dry weight, and water – up to 5-6 liters a day! (Use the fact that hypoglycemia “quenching” can not only carbohydrates but also protein and fluid overdose). I deliberately give here only general reasoning for this scheme, as its use requires strict monitoring by an experienced specialist!

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